E78.00 Pure hypercholesterolemia, unspecified

The ICD-10-CM code for Pure hypercholesterolemia, unspecified is E78.00 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Chapter

4: Endocrine, nutritional and metabolic diseases (E00-E89)

Section

E70-E88: Metabolic disorders (E70-E88)

Category E78

24 codes (18 billable)

FY2026 Status

Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to E78.00:

• Low-density-lipoprotein-type (LDL) hyperlipoproteinemia
• Hypercholesterolemia (essential) (primary) (pure)
• Cholesteremia
• Cholesterolemia (essential) (pure)
• Hyperbetalipoproteinemia (familial)
• Frederickson's hyperlipoproteinemia, type › IIA
• Cholesterol › elevated (high)
• Elevated, elevation › cholesterol

Inclusion Terms

• Fredrickson's hyperlipoproteinemia, type IIa
• Hyperbetalipoproteinemia
• Low-density-lipoprotein-type [LDL] hyperlipoproteinemia
• (Pure) hypercholesterolemia NOS

U.S. Hospital Utilization

• An estimated 1,798,300 U.S. inpatient stays in 2023 included E78.00 among the documented diagnoses.
• 125 stays listed it as the principal diagnosis.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

Diabetes mellitus (TOC entry)

a. Diabetes mellitus ................................................................................................................... 39

Obesity (TOC entry)

b. Obesity .................................................................................................................................. 42

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

• CMS — ICD-10-CM Official Code Set and Guidelines, FY2026
• CDC/NCHS — ICD-10-CM Files and Browser Tool
• AHRQ — HCUP National Inpatient Sample, Frequencies by Diagnosis Code (2016–2023)