G12.21 Amyotrophic lateral sclerosis

The ICD-10-CM code for Amyotrophic lateral sclerosis is G12.21 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Chapter

6: Diseases of the nervous system (G00-G99)

Section

G10-G14: Systemic atrophies primarily affecting the central nervous system (G10-G14)

Category G12

13 codes (11 billable)

FY2026 Status

Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to G12.21:

• Duchenne-Aran muscular atrophy
• Paralysis, paralytic (complete) (incomplete) › amyotrophic
• Amyotrophia, amyotrophy, amyotrophic › lateral sclerosis
• Sclerosis, sclerotic › amyotrophic (lateral)
• Sclerosis, sclerotic › lateral (amyotrophic) (descending) (spinal)
• Atrophy, atrophic (of) › Duchenne-Aran
• Atrophy, atrophic (of) › muscle, muscular (diffuse) (general) (idiopathic) (primary) › Duchenne-Aran
• Atrophy, atrophic (of) › muscle, muscular (diffuse) (general) (idiopathic) (primary) › progressive (bulbar)

U.S. Hospital Utilization

• An estimated 12,810 U.S. inpatient stays in 2023 included G12.21 among the documented diagnoses.
• 2,685 stays listed it as the principal diagnosis.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

Dominant/nondominant side (TOC entry)

a. Dominant/nondominant side ................................................................................................. 45

Pain - Category G89 (TOC entry)

b. Pain - Category G89.............................................................................................................. 45

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

• CMS — ICD-10-CM Official Code Set and Guidelines, FY2026
• CDC/NCHS — ICD-10-CM Files and Browser Tool
• AHRQ — HCUP National Inpatient Sample, Frequencies by Diagnosis Code (2016–2023)