D89 Other disorders involving the immune mechanism, not elsewhere classified

⚠ Non-Billable ICD-10-CM 2026
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The ICD-10-CM code for Other disorders involving the immune mechanism, not elsewhere classified is D89 (FY2026). It is a non-billable category code — select a more specific code below for claims.

Classification

Section
D80-D89: Certain disorders involving the immune mechanism (D80-D89)
Category D89
29 codes (24 billable)
FY2026 Status
Stable since FY2024
Excludes1
Not coded here. These conditions should NOT be coded together with D89.
  • hyperglobulinemia NOS (R77.1)
  • monoclonal gammopathy (of undetermined significance) (D47.2)
Excludes2
Not included here. These conditions are coded elsewhere but may be coded together if applicable.
  • transplant failure and rejection (T86.-)

Official Coding Guidelines

Chapter 3 TOC entry

3. Chapter 3: Disease of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) ............................................................................................. 39

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section I.C.3
Chapter 3 reserved for future guideline expansion

3. Chapter 3: Disease of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) Reserved for future guideline expansion

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section I.C.3

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

Cite This Page

Reference D89 with the canonical source and edition:

D89 — Other disorders involving the immune mechanism, not elsewhere classified. ICD-10 Coding Pro (ICD-10-CM FY2026). https://icd10codingpro.com/codes/D89

Canonical URL: https://icd10codingpro.com/codes/D89

Related Codes

More Specific Codes

D89.0 Polyclonal hypergammaglobulinemia D89.1 Cryoglobulinemia D89.2 Hypergammaglobulinemia, unspecified D89.3 Immune reconstitution syndrome D89.4 Mast cell activation syndrome and related disorders D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified D89.9 Disorder involving the immune mechanism, unspecified

All Codes in D89

Every most-specific code under D89 Other disorders involving the immune mechanism, not elsewhere classified (24 codes):

Show the complete D89 code list
D89.0 Polyclonal hypergammaglobulinemia D89.1 Cryoglobulinemia D89.2 Hypergammaglobulinemia, unspecified D89.3 Immune reconstitution syndrome D89.40 Mast cell activation, unspecified D89.41 Monoclonal mast cell activation syndrome D89.42 Idiopathic mast cell activation syndrome D89.43 Secondary mast cell activation D89.44 Hereditary alpha tryptasemia D89.49 Other mast cell activation disorder D89.810 Acute graft-versus-host disease D89.811 Chronic graft-versus-host disease D89.812 Acute on chronic graft-versus-host disease D89.813 Graft-versus-host disease, unspecified D89.82 Autoimmune lymphoproliferative syndrome [ALPS] D89.831 Cytokine release syndrome, grade 1 D89.832 Cytokine release syndrome, grade 2 D89.833 Cytokine release syndrome, grade 3 D89.834 Cytokine release syndrome, grade 4 D89.835 Cytokine release syndrome, grade 5 D89.839 Cytokine release syndrome, grade unspecified D89.84 IgG4-related disease D89.89 Other specified disorders involving the immune mechanism, not elsewhere classified D89.9 Disorder involving the immune mechanism, unspecified
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Reviewed by Prajwal Shrestha, CPC, CRC
Certified Professional Coder (CPC) and Certified Risk Adjustment Coder (CRC) · AAPC Member ID 01997614 · About · Editorial policy · Content last reviewed: 2025-10-01

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