D89.3 Immune reconstitution syndrome

✓ Billable ICD-10-CM 2026
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The ICD-10-CM code for Immune reconstitution syndrome is D89.3 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Section
D80-D89: Certain disorders involving the immune mechanism (D80-D89)
Category D89
29 codes (24 billable)
FY2026 Status
Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to D89.3:

  • Immune reconstitution (inflammatory) syndrome [IRIS]
  • Syndrome › immune reconstitution
  • Syndrome › immune reconstitution inflammatory [IRIS]
Use Additional Code
  • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Inclusion Terms

  • Immune reconstitution inflammatory syndrome [IRIS]

U.S. Hospital Utilization

  • An estimated 400 U.S. inpatient stays in 2023 included D89.3 among the documented diagnoses.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

Chapter 3 TOC entry

3. Chapter 3: Disease of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) ............................................................................................. 39

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section I.C.3
Reserved for future guideline expansion

Reserved for future guideline expansion ...................................................................................... 39

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section I.C.3.Reserved

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

Related Codes

Parent Code

D89 Other disorders involving the immune mechanism, not elsewhere classified

Related Codes in D89

D89 Other disorders involving the immune mechanism, not elsewhere classified D89.0 Polyclonal hypergammaglobulinemia D89.1 Cryoglobulinemia D89.2 Hypergammaglobulinemia, unspecified D89.4 Mast cell activation syndrome and related disorders D89.40 Mast cell activation, unspecified D89.41 Monoclonal mast cell activation syndrome D89.42 Idiopathic mast cell activation syndrome D89.43 Secondary mast cell activation D89.44 Hereditary alpha tryptasemia D89.49 Other mast cell activation disorder D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified D89.81 Graft-versus-host disease D89.810 Acute graft-versus-host disease D89.811 Chronic graft-versus-host disease D89.812 Acute on chronic graft-versus-host disease D89.813 Graft-versus-host disease, unspecified D89.82 Autoimmune lymphoproliferative syndrome [ALPS] D89.83 Cytokine release syndrome D89.831 Cytokine release syndrome, grade 1
Search all 70,000+ ICD-10-CM codes →
Reviewed by Prajwal Shrestha, CPC, CRC
Certified Professional Coder (CPC) and Certified Risk Adjustment Coder (CRC) · AAPC Member ID 01997614 · About · Editorial policy · Content last reviewed: 2025-10-01

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