D81.82 Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]
The ICD-10-CM code for Activated Phosphoinositide 3-kinase Delta Syndrome [APDS] is D81.82 (FY2026). It is a billable, claim-ready diagnosis code.
Classification
- Section
- D80-D89: Certain disorders involving the immune mechanism (D80-D89)
- Category D81
- 21 codes (17 billable)
- FY2026 Status
- Stable since FY2024
Also Known As
ICD-10-CM Alphabetic Index entries that lead to D81.82:
- Syndrome › activated phosphoinositide 3-kinase delta syndrome [APDS]
- Disease, diseased › p110d-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency [PASLI]
Inclusion Terms
- p110d-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency [PASLI] disease
U.S. Hospital Utilization
D81.82 appeared in too few sampled U.S. inpatient stays in 2023 to report a national estimate (AHRQ suppresses counts of 10 or fewer) — a rare inpatient diagnosis.
Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.
Official Coding Guidelines
Chapter 3 TOC entry3. Chapter 3: Disease of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) ............................................................................................. 39
Reserved for future guideline expansionReserved for future guideline expansion ...................................................................................... 39
Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026