D81.31 Severe combined immunodeficiency due to adenosine deaminase deficiency
The ICD-10-CM code for Severe combined immunodeficiency due to adenosine deaminase deficiency is D81.31 (FY2026). It is a billable, claim-ready diagnosis code.
Classification
- Section
- D80-D89: Certain disorders involving the immune mechanism (D80-D89)
- Category D81
- 21 codes (17 billable)
- FY2026 Status
- Stable since FY2024
Also Known As
ICD-10-CM Alphabetic Index entries that lead to D81.31:
- Immunodeficiency › severe combined (SCID) › due to adenosine deaminase deficiency
- Deficiency, deficient › adenosine deaminase (ADA) › with severe combined immunodeficiency (SCID)
Inclusion Terms
- ADA deficiency with SCID
- Adenosine deaminase [ADA] deficiency with severe combined immunodeficiency
U.S. Hospital Utilization
D81.31 appeared in too few sampled U.S. inpatient stays in 2023 to report a national estimate (AHRQ suppresses counts of 10 or fewer) — a rare inpatient diagnosis.
Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.
Official Coding Guidelines
Chapter 3 TOC entry3. Chapter 3: Disease of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) ............................................................................................. 39
Reserved for future guideline expansionReserved for future guideline expansion ...................................................................................... 39
Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026