D81.3 Adenosine deaminase [ADA] deficiency

⚠ Non-Billable ICD-10-CM 2026
Open D81.3 in Web App →

The ICD-10-CM code for Adenosine deaminase [ADA] deficiency is D81.3 (FY2026). It is a non-billable category code — select a more specific code below for claims.

Classification

Section
D80-D89: Certain disorders involving the immune mechanism (D80-D89)
Category D81
21 codes (17 billable)
FY2026 Status
Stable since FY2024

U.S. Hospital Utilization

  • An estimated 60 U.S. inpatient stays in 2017 included D81.3 among the documented diagnoses.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

Chapter 3 TOC entry

3. Chapter 3: Disease of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) ............................................................................................. 39

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section I.C.3
Reserved for future guideline expansion

Reserved for future guideline expansion ...................................................................................... 39

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section I.C.3.Reserved

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

Related Codes

Parent Code

D81 Combined immunodeficiencies

More Specific Codes

D81.30 Adenosine deaminase deficiency, unspecified D81.31 Severe combined immunodeficiency due to adenosine deaminase deficiency D81.32 Adenosine deaminase 2 deficiency D81.39 Other adenosine deaminase deficiency

Related Codes in D81

D81 Combined immunodeficiencies D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers D81.30 Adenosine deaminase deficiency, unspecified D81.31 Severe combined immunodeficiency due to adenosine deaminase deficiency D81.32 Adenosine deaminase 2 deficiency D81.39 Other adenosine deaminase deficiency D81.4 Nezelof's syndrome D81.5 Purine nucleoside phosphorylase [PNP] deficiency D81.6 Major histocompatibility complex class I deficiency D81.7 Major histocompatibility complex class II deficiency D81.8 Other combined immunodeficiencies D81.81 Biotin-dependent carboxylase deficiency D81.810 Biotinidase deficiency D81.818 Other biotin-dependent carboxylase deficiency D81.819 Biotin-dependent carboxylase deficiency, unspecified D81.82 Activated Phosphoinositide 3-kinase Delta Syndrome [APDS] D81.89 Other combined immunodeficiencies D81.9 Combined immunodeficiency, unspecified
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Reviewed by Prajwal Shrestha, CPC, CRC
Certified Professional Coder (CPC) and Certified Risk Adjustment Coder (CRC) · AAPC Member ID 01997614 · About · Editorial policy · Content last reviewed: 2025-10-01

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