D68.61 Antiphospholipid syndrome

✓ Billable ICD-10-CM 2026
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The ICD-10-CM code for Antiphospholipid syndrome is D68.61 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Section
D65-D69: Coagulation defects, purpura and other hemorrhagic conditions (D65-D69)
Category D68
32 codes (25 billable)
FY2026 Status
Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to D68.61:

  • Anticardiolipin syndrome
  • Syndrome › anticardiolipin (-antibody)
  • Syndrome › antiphospholipid (-antibody)
  • Antiphospholipid › antibody › syndrome
  • Antibody › anticardiolipin › with › hypercoagulable state
  • Antibody › antiphosphatidylserine › with › hypercoagulable state
  • Antibody › antiphosphatidylinositol › with › hypercoagulable state
  • Antibody › antiphosphatidylglycerol › with › hypercoagulable state
Excludes1
Not coded here. These conditions should NOT be coded together with D68.61.
  • anti-phospholipid antibody, finding without diagnosis (R76.0)
Excludes2
Not included here. These conditions are coded elsewhere but may be coded together if applicable.
  • anti-phospholipid antibody with hemorrhagic disorder (D68.312)
  • lupus anticoagulant syndrome (D68.62)

Inclusion Terms

  • Anticardiolipin syndrome
  • Antiphospholipid antibody syndrome

U.S. Hospital Utilization

  • An estimated 39,735 U.S. inpatient stays in 2023 included D68.61 among the documented diagnoses.
  • 415 stays listed it as the principal diagnosis.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

Chapter 3 TOC entry

3. Chapter 3: Disease of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) ............................................................................................. 39

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section I.C.3
Reserved for future guideline expansion

Reserved for future guideline expansion ...................................................................................... 39

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section I.C.3.Reserved

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

Related Codes

Parent Code

D68 Other coagulation defects

Related Codes in D68

D68 Other coagulation defects D68.0 Von Willebrand disease D68.00 Von Willebrand disease, unspecified D68.01 Von Willebrand disease, type 1 D68.02 Von Willebrand disease, type 2 D68.020 Von Willebrand disease, type 2A D68.021 Von Willebrand disease, type 2B D68.022 Von Willebrand disease, type 2M D68.023 Von Willebrand disease, type 2N D68.029 Von Willebrand disease, type 2, unspecified D68.03 Von Willebrand disease, type 3 D68.04 Acquired von Willebrand disease D68.09 Other von Willebrand disease D68.1 Hereditary factor XI deficiency D68.2 Hereditary deficiency of other clotting factors D68.3 Hemorrhagic disorder due to circulating anticoagulants D68.31 Hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors D68.311 Acquired hemophilia D68.312 Antiphospholipid antibody with hemorrhagic disorder D68.318 Other hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors
Search all 70,000+ ICD-10-CM codes →
Reviewed by Prajwal Shrestha, CPC, CRC
Certified Professional Coder (CPC) and Certified Risk Adjustment Coder (CRC) · AAPC Member ID 01997614 · About · Editorial policy · Content last reviewed: 2025-10-01

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