D57.4 Sickle-cell thalassemia

⚠ Non-Billable ICD-10-CM 2026
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The ICD-10-CM code for Sickle-cell thalassemia is D57.4 (FY2026). It is a non-billable category code — select a more specific code below for claims.

Classification

Section
D55-D59: Hemolytic anemias (D55-D59)
Category D57
53 codes (43 billable)
FY2026 Status
Stable since FY2024

Inclusion Terms

  • Sickle-cell beta thalassemia
  • Thalassemia Hb-S disease

Official Coding Guidelines

Chapter 3 TOC entry

3. Chapter 3: Disease of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) ............................................................................................. 39

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section I.C.3
Reserved for future guideline expansion

Reserved for future guideline expansion ...................................................................................... 39

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section I.C.3.Reserved

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

Related Codes

Parent Code

D57 Sickle-cell disorders

More Specific Codes

D57.40 Sickle-cell thalassemia without crisis D57.41 Sickle-cell thalassemia, unspecified, with crisis D57.411 Sickle-cell thalassemia, unspecified, with acute chest syndrome D57.412 Sickle-cell thalassemia, unspecified, with splenic sequestration D57.413 Sickle-cell thalassemia, unspecified, with cerebral vascular involvement D57.414 Sickle-cell thalassemia, unspecified, with dactylitis D57.418 Sickle-cell thalassemia, unspecified, with crisis with other specified complication D57.419 Sickle-cell thalassemia, unspecified, with crisis D57.42 Sickle-cell thalassemia beta zero without crisis D57.43 Sickle-cell thalassemia beta zero with crisis D57.431 Sickle-cell thalassemia beta zero with acute chest syndrome D57.432 Sickle-cell thalassemia beta zero with splenic sequestration D57.433 Sickle-cell thalassemia beta zero with cerebral vascular involvement D57.434 Sickle-cell thalassemia beta zero with dactylitis D57.438 Sickle-cell thalassemia beta zero with crisis with other specified complication D57.439 Sickle-cell thalassemia beta zero with crisis, unspecified D57.44 Sickle-cell thalassemia beta plus without crisis D57.45 Sickle-cell thalassemia beta plus with crisis D57.451 Sickle-cell thalassemia beta plus with acute chest syndrome D57.452 Sickle-cell thalassemia beta plus with splenic sequestration D57.453 Sickle-cell thalassemia beta plus with cerebral vascular involvement D57.454 Sickle-cell thalassemia beta plus with dactylitis D57.458 Sickle-cell thalassemia beta plus with crisis with other specified complication D57.459 Sickle-cell thalassemia beta plus with crisis, unspecified

Related Codes in D57

D57 Sickle-cell disorders D57.0 Hb-SS disease with crisis D57.00 Hb-SS disease with crisis, unspecified D57.01 Hb-SS disease with acute chest syndrome D57.02 Hb-SS disease with splenic sequestration D57.03 Hb-SS disease with cerebral vascular involvement D57.04 Hb-SS disease with dactylitis D57.09 Hb-SS disease with crisis with other specified complication D57.1 Sickle-cell disease without crisis D57.2 Sickle-cell/Hb-C disease D57.20 Sickle-cell/Hb-C disease without crisis D57.21 Sickle-cell/Hb-C disease with crisis D57.211 Sickle-cell/Hb-C disease with acute chest syndrome D57.212 Sickle-cell/Hb-C disease with splenic sequestration D57.213 Sickle-cell/Hb-C disease with cerebral vascular involvement D57.214 Sickle-cell/Hb-C disease with dactylitis D57.218 Sickle-cell/Hb-C disease with crisis with other specified complication D57.219 Sickle-cell/Hb-C disease with crisis, unspecified D57.3 Sickle-cell trait D57.40 Sickle-cell thalassemia without crisis
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Reviewed by Prajwal Shrestha, CPC, CRC
Certified Professional Coder (CPC) and Certified Risk Adjustment Coder (CRC) · AAPC Member ID 01997614 · About · Editorial policy · Content last reviewed: 2025-10-01

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