D57.451 Sickle-cell thalassemia beta plus with acute chest syndrome

The ICD-10-CM code for Sickle-cell thalassemia beta plus with acute chest syndrome is D57.451 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Chapter

3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)

Section

D55-D59: Hemolytic anemias (D55-D59)

Category D57

53 codes (43 billable)

FY2026 Status

Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to D57.451:

• Disease, diseased › hemoglobin or Hb › S or SS › beta plus › with › acute chest syndrome
• Disease, diseased › sickle-cell › thalassemia › beta plus › with › acute chest syndrome

Inclusion Terms

• HbS-beta plus with acute chest syndrome
• Sickle-cell beta plus with acute chest syndrome

U.S. Hospital Utilization

• An estimated 205 U.S. inpatient stays in 2023 included D57.451 among the documented diagnoses.
• 160 stays listed it as the principal diagnosis.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

Chapter 3 TOC entry

3. Chapter 3: Disease of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) ............................................................................................. 39

Reserved for future guideline expansion

Reserved for future guideline expansion ...................................................................................... 39

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

• CMS — ICD-10-CM Official Code Set and Guidelines, FY2026
• CDC/NCHS — ICD-10-CM Files and Browser Tool
• AHRQ — HCUP National Inpatient Sample, Frequencies by Diagnosis Code (2016–2023)