D55.29 Anemia due to other disorders of glycolytic enzymes

The ICD-10-CM code for Anemia due to other disorders of glycolytic enzymes is D55.29 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Chapter

3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)

Section

D55-D59: Hemolytic anemias (D55-D59)

Category D55

9 codes (7 billable)

FY2026 Status

Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to D55.29:

• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › hexokinase deficiency
• Disorder (of) › anaerobic glycolysis with anemia
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › glyceraldehyde phosphate dehydrogenase
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › hexokinase
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › phosphofructo-aldolase
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › 2, 3 PG
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › phosphoglycerate kinase
• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › 2, 3 diphosphoglycurate mutase

Inclusion Terms

• Hexokinase deficiency anemia
• Triose-phosphate isomerase deficiency anemia

U.S. Hospital Utilization

D55.29 appeared in too few sampled U.S. inpatient stays in 2023 to report a national estimate (AHRQ suppresses counts of 10 or fewer) — a rare inpatient diagnosis.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

Chapter 3 TOC entry

3. Chapter 3: Disease of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) ............................................................................................. 39

Reserved for future guideline expansion

Reserved for future guideline expansion ...................................................................................... 39

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

• CMS — ICD-10-CM Official Code Set and Guidelines, FY2026
• CDC/NCHS — ICD-10-CM Files and Browser Tool
• AHRQ — HCUP National Inpatient Sample, Frequencies by Diagnosis Code (2016–2023)