D55.21 Anemia due to pyruvate kinase deficiency
The ICD-10-CM code for Anemia due to pyruvate kinase deficiency is D55.21 (FY2026). It is a billable, claim-ready diagnosis code.
Classification
- Section
- D55-D59: Hemolytic anemias (D55-D59)
- Category D55
- 9 codes (7 billable)
- FY2026 Status
- Stable since FY2024
Also Known As
ICD-10-CM Alphabetic Index entries that lead to D55.21:
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › pyruvate kinase deficiency
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › PK
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › pyruvate kinase
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › hemolytic › nonspherocytic › congenital or hereditary NEC › pyruvate kinase deficiency
Inclusion Terms
- PK deficiency anemia
- Pyruvate kinase deficiency anemia
U.S. Hospital Utilization
- An estimated 140 U.S. inpatient stays in 2023 included D55.21 among the documented diagnoses.
Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.
Official Coding Guidelines
Chapter 3 TOC entry3. Chapter 3: Disease of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) ............................................................................................. 39
Reserved for future guideline expansionReserved for future guideline expansion ...................................................................................... 39
Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026