D46.22 Refractory anemia with excess of blasts 2

The ICD-10-CM code for Refractory anemia with excess of blasts 2 is D46.22 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Chapter

2: Neoplasms (C00-D49)

Section

D37-D48: Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes (D37-D48)

Category D46

13 codes (11 billable)

FY2026 Status

Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to D46.22:

• Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › refractory › with › excess of blasts › 2 (RAEB 2)

Inclusion Terms

• RAEB 2

U.S. Hospital Utilization

• An estimated 380 U.S. inpatient stays in 2023 included D46.22 among the documented diagnoses.
• 100 stays listed it as the principal diagnosis.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

Tx of primary site (TOC entry)

a. Admission/Encounter for treatment of primary site ............................................................. 33

Tx of secondary site (TOC entry)

b. Admission/Encounter for treatment of secondary site .......................................................... 33

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

• CMS — ICD-10-CM Official Code Set and Guidelines, FY2026
• CDC/NCHS — ICD-10-CM Files and Browser Tool
• AHRQ — HCUP National Inpatient Sample, Frequencies by Diagnosis Code (2016–2023)

Cite This Page

Reference D46.22 with the canonical source and edition:

D46.22 — Refractory anemia with excess of blasts 2. ICD-10 Coding Pro (ICD-10-CM FY2026). https://icd10codingpro.com/codes/D46.22

Canonical URL: https://icd10codingpro.com/codes/D46.22