D46.C Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality

The ICD-10-CM code for Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality is D46.C (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Chapter

2: Neoplasms (C00-D49)

Section

D37-D48: Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes (D37-D48)

Category D46

13 codes (11 billable)

FY2026 Status

Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to D46.C:

• Syndrome › 5q minus NOS
• Myelodysplastic syndrome › with › 5q deletion
• Myelodysplastic syndrome › with › isolated del (5q) chromosomal abnormality
• Syndrome › myelodysplastic › with › isolated del (5q) chromosomal abnormality
• Syndrome › myelodysplastic › with › 5q deletion

Inclusion Terms

• Myelodysplastic syndrome with 5q deletion
• 5q minus syndrome NOS

U.S. Hospital Utilization

• An estimated 1,180 U.S. inpatient stays in 2023 included D46.C among the documented diagnoses.
• 170 stays listed it as the principal diagnosis.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

Tx of primary site (TOC entry)

a. Admission/Encounter for treatment of primary site ............................................................. 33

Tx of secondary site (TOC entry)

b. Admission/Encounter for treatment of secondary site .......................................................... 33

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

• CMS — ICD-10-CM Official Code Set and Guidelines, FY2026
• CDC/NCHS — ICD-10-CM Files and Browser Tool
• AHRQ — HCUP National Inpatient Sample, Frequencies by Diagnosis Code (2016–2023)