Z15 Genetic susceptibility to disease
The ICD-10-CM code for Genetic susceptibility to disease is Z15 (FY2026). It is a non-billable category code — select a more specific code below for claims.
Classification
- Section
- Z14-Z15: Genetic carrier and genetic susceptibility to disease (Z14-Z15)
- Category Z15
- 18 codes (14 billable)
- FY2026 Status
- Stable since FY2024
Official Coding Guidelines
Z15: sequencing/principal-first-listed guidance and counselingZ15 Genetic susceptibility to disease Genetic susceptibility indicates that a person has a gene that increases the risk of that person developing the disease. Codes from category Z15 should generally not be used as principal or first-listed codes. If the patient has the condition to which he/she is susceptible, and that condition is the reason for the encounter, the code for the current condition should be sequenced first. If the patient is being seen for follow-up after completed treatment for this condition, and the condition no longer exists, a follow-up code should be sequenced first, followed by the appropriate personal history and genetic susceptibility codes. If the purpose of the encounter is genetic counseling associated with procreative management, code Z31.5, Encounter for genetic counseling, should be assigned as the first-listed code, followed by a code from category Z15. Additional codes should be assigned for any applicable family or personal history.
Used with any code in range A00.0-T88.9, Z00-Z991) Used with any code in the range of A00.0-T88.9, Z00-Z99 An external cause code may be used with any code in the range of A00.0-T88.9, Z00-Z99, classification that represents a health condition due to an external cause. Though they are most applicable to injuries, they are also valid for use with such things as infections or diseases due to an external source, and other health conditions, such as a heart attack that occurs during strenuous physical activity.
Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026