T80.5 Anaphylactic reaction due to serum

⚠ Non-Billable ICD-10-CM 2026
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The ICD-10-CM code for Anaphylactic reaction due to serum is T80.5 (FY2026). It is a non-billable category code — select a more specific code below for claims.

Classification

Section
T80-T88: Complications of surgical and medical care, not elsewhere classified (T80-T88)
Category T80
53 codes (38 billable)
FY2026 Status
Stable since FY2024
Excludes1
Not coded here. These conditions should NOT be coded together with T80.5.
  • ABO incompatibility reaction due to transfusion of blood or blood products (T80.3-)
  • allergic reaction or shock NOS (T78.2)
  • anaphylactic reaction or shock NOS (T78.2)
  • anaphylactic reaction or shock due to adverse effect of correct medicinal substance properly administered (T88.6)
  • other serum reaction (T80.6-)

Inclusion Terms

  • Allergic shock due to serum
  • Anaphylactic shock due to serum
  • Anaphylactoid reaction due to serum
  • Anaphylaxis due to serum

Official Coding Guidelines

Complications of surgery and other medical care

G. Complications of surgery and other medical care When the admission is for treatment of a complication resulting from surgery or other medical care, the complication code is sequenced as the principal diagnosis. If the complication is classified to the T80-T88 series and the code lacks the necessary specificity in describing the complication, an additional code for the specific complication should be assigned.

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section II.G
Sequence blood vessel/nerve injury first (fragment)

injury is to the blood vessels or nerves, that injury should be sequenced first.

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section I.C.19.b.2

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

Related Codes

Parent Code

T80 Complications following infusion, transfusion and therapeutic injection

More Specific Codes

Related Codes in T80

Search all 70,000+ ICD-10-CM codes →
Reviewed by Prajwal Shrestha, CPC, CRC
Certified Professional Coder (CPC) and Certified Risk Adjustment Coder (CRC) · AAPC Member ID 01997614 · About · Editorial policy · Content last reviewed: 2025-10-01

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