T65 Toxic effect of other and unspecified substances

⚠ Non-Billable ICD-10-CM 2026
Create your free account → Open T65 in the app →

Get what a quick lookup can't: the AI assistant for official-guideline questions, HCC risk-adjustment mappings (CMS-HCC V24/V28, RxHCC), FDA drug indications, and AHA Coding Clinic references for T65.

The ICD-10-CM code for Toxic effect of other and unspecified substances is T65 (FY2026). It is a non-billable category code — select a more specific code below for claims.

Classification

Section
T51-T65: Toxic effects of substances chiefly nonmedicinal as to source (T51-T65)
Category T65
84 codes (60 billable)
FY2026 Status
Stable since FY2024

Official Coding Guidelines

T36-T65 are combination codes; no additional external cause code

e. Adverse Effects, Poisoning, Underdosing and Toxic Effects Codes in categories T36-T65 are combination codes that include the substance that was taken as well as the intent. No additional external cause code is required for poisonings, toxic effects, adverse effects and underdosing codes.

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section I.C.19.e
Toxic effects: code T51-T65 first, then manifestations

(d) Toxic Effects When a harmful substance is ingested or comes in contact with a person, this is classified as a toxic effect. The toxic effect codes are in categories T51-T65. When coding a toxic effect, assign the toxic effect code first, followed by codes for all associated manifestations of the toxic effect.

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section I.C.19.e.(d)

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

Cite This Page

Reference T65 with the canonical source and edition:

T65 — Toxic effect of other and unspecified substances. ICD-10 Coding Pro (ICD-10-CM FY2026). https://icd10codingpro.com/codes/T65

Canonical URL: https://icd10codingpro.com/codes/T65

Related Codes

All Codes in T65

Every most-specific code under T65 Toxic effect of other and unspecified substances (60 codes):

Show the complete T65 code list
T65.0X1 Toxic effect of cyanides, accidental (unintentional) T65.0X2 Toxic effect of cyanides, intentional self-harm T65.0X3 Toxic effect of cyanides, assault T65.0X4 Toxic effect of cyanides, undetermined T65.1X1 Toxic effect of strychnine and its salts, accidental (unintentional) T65.1X2 Toxic effect of strychnine and its salts, intentional self-harm T65.1X3 Toxic effect of strychnine and its salts, assault T65.1X4 Toxic effect of strychnine and its salts, undetermined T65.211 Toxic effect of chewing tobacco, accidental (unintentional) T65.212 Toxic effect of chewing tobacco, intentional self-harm T65.213 Toxic effect of chewing tobacco, assault T65.214 Toxic effect of chewing tobacco, undetermined T65.221 Toxic effect of tobacco cigarettes, accidental (unintentional) T65.222 Toxic effect of tobacco cigarettes, intentional self-harm T65.223 Toxic effect of tobacco cigarettes, assault T65.224 Toxic effect of tobacco cigarettes, undetermined T65.291 Toxic effect of other tobacco and nicotine, accidental (unintentional) T65.292 Toxic effect of other tobacco and nicotine, intentional self-harm T65.293 Toxic effect of other tobacco and nicotine, assault T65.294 Toxic effect of other tobacco and nicotine, undetermined T65.3X1 Toxic effect of nitroderivatives and aminoderivatives of benzene and its homologues, accidental (unintentional) T65.3X2 Toxic effect of nitroderivatives and aminoderivatives of benzene and its homologues, intentional self-harm T65.3X3 Toxic effect of nitroderivatives and aminoderivatives of benzene and its homologues, assault T65.3X4 Toxic effect of nitroderivatives and aminoderivatives of benzene and its homologues, undetermined T65.4X1 Toxic effect of carbon disulfide, accidental (unintentional) T65.4X2 Toxic effect of carbon disulfide, intentional self-harm T65.4X3 Toxic effect of carbon disulfide, assault T65.4X4 Toxic effect of carbon disulfide, undetermined T65.5X1 Toxic effect of nitroglycerin and other nitric acids and esters, accidental (unintentional) T65.5X2 Toxic effect of nitroglycerin and other nitric acids and esters, intentional self-harm T65.5X3 Toxic effect of nitroglycerin and other nitric acids and esters, assault T65.5X4 Toxic effect of nitroglycerin and other nitric acids and esters, undetermined T65.6X1 Toxic effect of paints and dyes, not elsewhere classified, accidental (unintentional) T65.6X2 Toxic effect of paints and dyes, not elsewhere classified, intentional self-harm T65.6X3 Toxic effect of paints and dyes, not elsewhere classified, assault T65.6X4 Toxic effect of paints and dyes, not elsewhere classified, undetermined T65.811 Toxic effect of latex, accidental (unintentional) T65.812 Toxic effect of latex, intentional self-harm T65.813 Toxic effect of latex, assault T65.814 Toxic effect of latex, undetermined T65.821 Toxic effect of harmful algae and algae toxins, accidental (unintentional) T65.822 Toxic effect of harmful algae and algae toxins, intentional self-harm T65.823 Toxic effect of harmful algae and algae toxins, assault T65.824 Toxic effect of harmful algae and algae toxins, undetermined T65.831 Toxic effect of fiberglass, accidental (unintentional) T65.832 Toxic effect of fiberglass, intentional self-harm T65.833 Toxic effect of fiberglass, assault T65.834 Toxic effect of fiberglass, undetermined T65.841 Toxic effect of xylazine, accidental (unintentional) T65.842 Toxic effect of xylazine, intentional self-harm T65.843 Toxic effect of xylazine, assault T65.844 Toxic effect of xylazine, undetermined T65.891 Toxic effect of other specified substances, accidental (unintentional) T65.892 Toxic effect of other specified substances, intentional self-harm T65.893 Toxic effect of other specified substances, assault T65.894 Toxic effect of other specified substances, undetermined T65.91 Toxic effect of unspecified substance, accidental (unintentional) T65.92 Toxic effect of unspecified substance, intentional self-harm T65.93 Toxic effect of unspecified substance, assault T65.94 Toxic effect of unspecified substance, undetermined
Search all 70,000+ ICD-10-CM codes →
Reviewed by Prajwal Shrestha, CPC, CRC
Certified Professional Coder (CPC) and Certified Risk Adjustment Coder (CRC) · AAPC Member ID 01997614 · About · Editorial policy · Content last reviewed: 2025-10-01

Get HCC Mappings, Clinical Summaries, and More

Access premium features including HCC risk adjustment, FDA drug indications, AI coding assistant, and comprehensive clinical context.

Start Free Trial