I25.110 Atherosclerotic heart disease of native coronary artery with unstable angina pectoris

✓ Billable ICD-10-CM 2026
Open I25.110 in Web App →

The ICD-10-CM code for Atherosclerotic heart disease of native coronary artery with unstable angina pectoris is I25.110 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Section
I20-I25: Ischemic heart diseases (I20-I25)
Category I25
70 codes (56 billable)
FY2026 Status
Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to I25.110:

  • Arteriosclerosis, arteriosclerotic (diffuse) (obliterans) (of) (senile) (with calcification) › coronary (artery) › native vessel › with › angina pectoris › unstable
Excludes1
Not coded here. These conditions should NOT be coded together with I25.110.
  • unstable angina without atherosclerotic heart disease (I20.0)

U.S. Hospital Utilization

  • An estimated 252,110 U.S. inpatient stays in 2023 included I25.110 among the documented diagnoses.
  • 119,770 stays listed it as the principal diagnosis.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

Presumed relationship due to Index term “with”

The classification presumes a causal relationship between hypertension and heart involvement and between hypertension and kidney involvement, as the two conditions are linked by the term “with” in the Alphabetic Index. These conditions should be coded as related even in the absence of provider documentation explicitly linking them, unless the documentation clearly states the conditions are unrelated.

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section I.C.9.a
Provider must link conditions not specifically indexed as related

For hypertension and conditions not specifically linked by relational terms such as “with,” “associated with” or “due to” in the classification, provider documentation must link the conditions in order to code them as related.

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section I.C.9.a

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

Related Codes

Parent Code

I25 Chronic ischemic heart disease

Related Codes in I25

Search all 70,000+ ICD-10-CM codes →
Reviewed by Prajwal Shrestha, CPC, CRC
Certified Professional Coder (CPC) and Certified Risk Adjustment Coder (CRC) · AAPC Member ID 01997614 · About · Editorial policy · Content last reviewed: 2025-10-01

Get HCC Mappings, Clinical Summaries, and More

Access premium features including HCC risk adjustment, FDA drug indications, AI coding assistant, and comprehensive clinical context.

Start Free Trial