I25.10 Atherosclerotic heart disease of native coronary artery without angina pectoris

The ICD-10-CM code for Atherosclerotic heart disease of native coronary artery without angina pectoris is I25.10 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Chapter

9: Diseases of the circulatory system (I00-I99)

Section

I20-I25: Ischemic heart diseases (I20-I25)

Category I25

70 codes (56 billable)

FY2026 Status

Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to I25.10:

• Disease, diseased › cardiovascular (atherosclerotic)
• Arteriosclerosis, arteriosclerotic (diffuse) (obliterans) (of) (senile) (with calcification) › coronary (artery)
• Atheroma, atheromatous › coronary (artery)
• Sclerosis, sclerotic › coronary (artery)
• Atherosclerosis › coronary › artery
• Disease, diseased › artery › coronary
• Disease, diseased › heart (organic) › ischemic (chronic or with a stated duration of over 4 weeks) › atherosclerotic (of)

Inclusion Terms

• Atherosclerotic heart disease NOS

U.S. Hospital Utilization

• An estimated 5,184,715 U.S. inpatient stays in 2023 included I25.10 among the documented diagnoses.
• 94,630 stays listed it as the principal diagnosis.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Prevalence & Statistics

• About 1 in 20 U.S. adults age 20 and older (about 5%) have coronary artery disease, the most common type of heart disease, which killed 371,506 people in 2022. (CDC Heart Disease Facts, 2022)

Official Coding Guidelines

Presumed relationship due to Index term “with”

The classification presumes a causal relationship between hypertension and heart involvement and between hypertension and kidney involvement, as the two conditions are linked by the term “with” in the Alphabetic Index. These conditions should be coded as related even in the absence of provider documentation explicitly linking them, unless the documentation clearly states the conditions are unrelated.

Provider must link conditions not specifically indexed as related

For hypertension and conditions not specifically linked by relational terms such as “with,” “associated with” or “due to” in the classification, provider documentation must link the conditions in order to code them as related.

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

• CMS — ICD-10-CM Official Code Set and Guidelines, FY2026
• CDC/NCHS — ICD-10-CM Files and Browser Tool
• AHRQ — HCUP National Inpatient Sample, Frequencies by Diagnosis Code (2016–2023)
• CDC Heart Disease Facts (2022)