E88.43 Disorders of mitochondrial tRNA synthetases
The ICD-10-CM code for Disorders of mitochondrial tRNA synthetases is E88.43 (FY2026). It is a billable, claim-ready diagnosis code.
Classification
- Section
- E70-E88: Metabolic disorders (E70-E88)
- Category E88
- 30 codes (24 billable)
- FY2026 Status
- Stable since FY2024
Also Known As
ICD-10-CM Alphabetic Index entries that lead to E88.43:
- LTBL (leukoencephalopathy with thalamus - brainstem involvement - high lactate)
- LBSL (leukoencephalopathy with brainstem - spinal cord involvement - lactate elevation)
- Leukoencephalopathy › with › brainstem - spinal cord involvement - lactate elevation
- Leukoencephalopathy › with › thalamus - brainstem involvement - high lactate
- Disorder (of) › metabolism NOS › mitochondrial › aminoacyl-tRNA synthetase
- Disorder (of) › metabolism NOS › mitochondrial › ARS2-related
- Disorder (of) › metabolism NOS › mitochondrial › tRNA synthetases
Inclusion Terms
- ARS2-related mitochondrial disorders
- LBSL
- Leukoencephalopathy with brainstem - spinal cord involvement - lactate elevation
- Leukoencephalopathy with thalamus - brainstem involvement - high lactate
- LTBL
- Mitochondrial aminoacyl-tRNA synthetase disorders
U.S. Hospital Utilization
E88.43 appeared in too few sampled U.S. inpatient stays in 2023 to report a national estimate (AHRQ suppresses counts of 10 or fewer) — a rare inpatient diagnosis.
Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.
Official Coding Guidelines
Diabetes mellitus (TOC entry)a. Diabetes mellitus ................................................................................................................... 39
Obesity (TOC entry)b. Obesity .................................................................................................................................. 42
Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026