E88.3 Tumor lysis syndrome

The ICD-10-CM code for Tumor lysis syndrome is E88.3 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Chapter

4: Endocrine, nutritional and metabolic diseases (E00-E89)

Section

E70-E88: Metabolic disorders (E70-E88)

Category E88

30 codes (24 billable)

FY2026 Status

Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to E88.3:

• Tumor lysis syndrome (following antineoplastic chemotherapy) (spontaneous) NEC
• Syndrome › tumor lysis (following antineoplastic chemotherapy) (spontaneous) NEC

Inclusion Terms

• Tumor lysis syndrome (spontaneous)
• Tumor lysis syndrome following antineoplastic drug chemotherapy

U.S. Hospital Utilization

• An estimated 19,125 U.S. inpatient stays in 2023 included E88.3 among the documented diagnoses.
• 1,085 stays listed it as the principal diagnosis.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

Diabetes mellitus (TOC entry)

a. Diabetes mellitus ................................................................................................................... 39

Obesity (TOC entry)

b. Obesity .................................................................................................................................. 42

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

• CMS — ICD-10-CM Official Code Set and Guidelines, FY2026
• CDC/NCHS — ICD-10-CM Files and Browser Tool
• AHRQ — HCUP National Inpatient Sample, Frequencies by Diagnosis Code (2016–2023)