E72.4 Disorders of ornithine metabolism

The ICD-10-CM code for Disorders of ornithine metabolism is E72.4 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Chapter

4: Endocrine, nutritional and metabolic diseases (E00-E89)

Section

E70-E88: Metabolic disorders (E70-E88)

Category E72

39 codes (31 billable)

FY2026 Status

Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to E72.4:

• Ornithinemia (Type I) (Type II)
• Hyperornithinemia
• Ornithine metabolism disorder
• Deficiency, deficient › ornithine transcarbamylase
• Disorder (of) › ornithine metabolism
• Hyperaminoaciduria › ornithine
• Syndrome › hyperammonemia-hyperornithinemia-homocitrullinemia
• Disorder (of) › metabolism NOS › ornithine

Inclusion Terms

• Hyperammonemia-Hyperornithinemia-Homocitrullinemia syndrome
• Ornithinemia (types I, II)
• Ornithine transcarbamylase deficiency

U.S. Hospital Utilization

• An estimated 2,575 U.S. inpatient stays in 2023 included E72.4 among the documented diagnoses.
• 250 stays listed it as the principal diagnosis.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

Diabetes mellitus (TOC entry)

a. Diabetes mellitus ................................................................................................................... 39

Obesity (TOC entry)

b. Obesity .................................................................................................................................. 42

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

• CMS — ICD-10-CM Official Code Set and Guidelines, FY2026
• CDC/NCHS — ICD-10-CM Files and Browser Tool
• AHRQ — HCUP National Inpatient Sample, Frequencies by Diagnosis Code (2016–2023)