E34.321 Primary insulin-like growth factor-1 (IGF-1) deficiency
The ICD-10-CM code for Primary insulin-like growth factor-1 (IGF-1) deficiency is E34.321 (FY2026). It is a billable, claim-ready diagnosis code.
Classification
- Section
- E20-E35: Disorders of other endocrine glands (E20-E35)
- Category E34
- 23 codes (18 billable)
- FY2026 Status
- Stable since FY2024
Also Known As
ICD-10-CM Alphabetic Index entries that lead to E34.321:
- Dwarfism › Laron-type
- Short, shortening, shortness › stature (child) (hereditary) (idiopathic) NEC › Laron-type
- Short, shortening, shortness › stature (child) (hereditary) (idiopathic) NEC › due to › genetic causes › acid-labile subunit gene (IGFALS) defect
- Short, shortening, shortness › stature (child) (hereditary) (idiopathic) NEC › due to › genetic causes › growth hormone gene 1 (GH1) defect with growth hormone neutralizing antibodies
- Short, shortening, shortness › stature (child) (hereditary) (idiopathic) NEC › due to › genetic causes › primary insulin-like growth factor-1 (IGF-1) deficiency
- Short, shortening, shortness › stature (child) (hereditary) (idiopathic) NEC › due to › genetic causes › growth hormone insensitivity syndrome (GHIS)
- Short, shortening, shortness › stature (child) (hereditary) (idiopathic) NEC › due to › genetic causes › insulin-like growth factor 1 gene (IGF1) defect
- Short, shortening, shortness › stature (child) (hereditary) (idiopathic) NEC › due to › genetic causes › severe primary insulin-like growth factor-1 deficiency (SPIGFD)
Inclusion Terms
- Acid-labile subunit gene (IGFALS) defect
- Growth hormone gene 1 (GH1) defect with growth hormone neutralizing antibodies
- Growth hormone insensitivity syndrome (GHIS)
- Insulin-like growth factor 1 gene (IGF1) defect
- Laron type short stature
- Severe primary insulin-like growth factor-1 deficiency (SPIGFD)
- Signal transducer and activator of transcription 5B gene (STAT5b) defect
U.S. Hospital Utilization
E34.321 appeared in too few sampled U.S. inpatient stays in 2023 to report a national estimate (AHRQ suppresses counts of 10 or fewer) — a rare inpatient diagnosis.
Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.
Official Coding Guidelines
Diabetes mellitus (TOC entry)a. Diabetes mellitus ................................................................................................................... 39
Obesity (TOC entry)b. Obesity .................................................................................................................................. 42
Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026