E16.3 Increased secretion of glucagon

The ICD-10-CM code for Increased secretion of glucagon is E16.3 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Chapter

4: Endocrine, nutritional and metabolic diseases (E00-E89)

Section

E15-E16: Other disorders of glucose regulation and pancreatic internal secretion (E15-E16)

Category E16

12 codes (10 billable)

FY2026 Status

Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to E16.3:

• Abnormal, abnormality, abnormalities › glucagon secretion
• Excess, excessive, excessively › glucagon
• Hypersecretion › glucagon
• Abnormal, abnormality, abnormalities › secretion › glucagon
• Increase, increased › secretion › glucagon
• Hyperplasia, hyperplastic › pancreatic islet cells › alpha › with excess › glucagon

Inclusion Terms

• Hyperplasia of pancreatic endocrine cells with glucagon excess

U.S. Hospital Utilization

E16.3 appeared in too few sampled U.S. inpatient stays in 2021 to report a national estimate (AHRQ suppresses counts of 10 or fewer) — a rare inpatient diagnosis.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

Diabetes mellitus (TOC entry)

a. Diabetes mellitus ................................................................................................................... 39

Obesity (TOC entry)

b. Obesity .................................................................................................................................. 42

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

• CMS — ICD-10-CM Official Code Set and Guidelines, FY2026
• CDC/NCHS — ICD-10-CM Files and Browser Tool
• AHRQ — HCUP National Inpatient Sample, Frequencies by Diagnosis Code (2016–2023)