E08.21 Diabetes mellitus due to underlying condition with diabetic nephropathy

✓ Billable ICD-10-CM 2026
Open E08.21 in the app →

Get what a quick lookup can't: the AI assistant for official-guideline questions, HCC risk-adjustment mappings (CMS-HCC V24/V28, RxHCC), FDA drug indications, and AHA Coding Clinic references for E08.21.

The ICD-10-CM code for Diabetes mellitus due to underlying condition with diabetic nephropathy is E08.21 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Section
E08-E13: Diabetes mellitus (E08-E13)
Category E08
64 codes (47 billable)
FY2026 Status
Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to E08.21:

  • Diabetes, diabetic (mellitus) (sugar) › due to underlying condition › with › glomerulosclerosis, intercapillary
  • Diabetes, diabetic (mellitus) (sugar) › due to underlying condition › with › glomerulonephrosis, intracapillary
  • Diabetes, diabetic (mellitus) (sugar) › due to underlying condition › with › Kimmelstiel-Wilson disease
  • Diabetes, diabetic (mellitus) (sugar) › due to underlying condition › with › nephropathy

Inclusion Terms

  • Diabetes mellitus due to underlying condition with intercapillary glomerulosclerosis
  • Diabetes mellitus due to underlying condition with intracapillary glomerulonephrosis
  • Diabetes mellitus due to underlying condition with Kimmelstiel-Wilson disease

U.S. Hospital Utilization

  • An estimated 150 U.S. inpatient stays in 2023 included E08.21 among the documented diagnoses.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

Sequence O24 first, then diabetes code(s) from Chapter 4

Diabetes mellitus in pregnancy, childbirth, and the puerperium, first, followed by the appropriate diabetes code(s) (E08-E13) from Chapter 4.

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section I.C.15.g
Diabetes mellitus (TOC entry)

a. Diabetes mellitus ................................................................................................................... 39

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section I.C.4.a

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

Cite This Page

Reference E08.21 with the canonical source and edition:

E08.21 — Diabetes mellitus due to underlying condition with diabetic nephropathy. ICD-10 Coding Pro (ICD-10-CM FY2026). https://icd10codingpro.com/codes/E08.21

Canonical URL: https://icd10codingpro.com/codes/E08.21

Related Codes

Parent Code

E08 Diabetes mellitus due to underlying condition

Related Codes in E08

E08 Diabetes mellitus due to underlying condition E08.0 Diabetes mellitus due to underlying condition with hyperosmolarity E08.00 Diabetes mellitus due to underlying condition with hyperosmolarity without nonketotic hyperglycemic-hyperosmolar coma (NKHHC) E08.01 Diabetes mellitus due to underlying condition with hyperosmolarity with coma E08.1 Diabetes mellitus due to underlying condition with ketoacidosis E08.10 Diabetes mellitus due to underlying condition with ketoacidosis without coma E08.11 Diabetes mellitus due to underlying condition with ketoacidosis with coma E08.2 Diabetes mellitus due to underlying condition with kidney complications E08.22 Diabetes mellitus due to underlying condition with diabetic chronic kidney disease E08.29 Diabetes mellitus due to underlying condition with other diabetic kidney complication E08.3 Diabetes mellitus due to underlying condition with ophthalmic complications E08.31 Diabetes mellitus due to underlying condition with unspecified diabetic retinopathy E08.311 Diabetes mellitus due to underlying condition with unspecified diabetic retinopathy with macular edema E08.319 Diabetes mellitus due to underlying condition with unspecified diabetic retinopathy without macular edema E08.32 Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy E08.321 Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy with macular edema E08.329 Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy without macular edema E08.33 Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy E08.331 Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy with macular edema E08.339 Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy without macular edema
Search all 70,000+ ICD-10-CM codes →
Reviewed by Prajwal Shrestha, CPC, CRC
Certified Professional Coder (CPC) and Certified Risk Adjustment Coder (CRC) · AAPC Member ID 01997614 · About · Editorial policy · Content last reviewed: 2025-10-01

Get HCC Mappings, Clinical Summaries, and More

Access premium features including HCC risk adjustment, FDA drug indications, AI coding assistant, and comprehensive clinical context.

Start Free Trial