C49 Malignant neoplasm of other connective and soft tissue

⚠ Non-Billable ICD-10-CM 2026
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The ICD-10-CM code for Malignant neoplasm of other connective and soft tissue is C49 (FY2026). It is a non-billable category code — select a more specific code below for claims.

Classification

Section
C45-C49: Malignant neoplasms of mesothelial and soft tissue (C45-C49)
Category C49
24 codes (20 billable)
FY2026 Status
Stable since FY2024
Includes
  • malignant neoplasm of blood vessel
  • malignant neoplasm of bursa
  • malignant neoplasm of cartilage
  • malignant neoplasm of fascia
  • malignant neoplasm of fat
  • malignant neoplasm of ligament, except uterine
  • malignant neoplasm of lymphatic vessel
  • malignant neoplasm of muscle
  • malignant neoplasm of synovia
  • malignant neoplasm of tendon (sheath)
Excludes1
Not coded here. These conditions should NOT be coded together with C49.
  • malignant neoplasm of cartilage (of):
  • articular (C40-C41)
  • larynx (C32.3)
  • nose (C30.0)
  • malignant neoplasm of connective tissue of breast (C50.-)
Excludes2
Not included here. These conditions are coded elsewhere but may be coded together if applicable.
  • Kaposi's sarcoma of soft tissue (C46.1)
  • malignant neoplasm of heart (C38.0)
  • malignant neoplasm of peripheral nerves and autonomic nervous system (C47.-)
  • malignant neoplasm of peritoneum (C48.2)
  • malignant neoplasm of retroperitoneum (C48.0)
  • malignant neoplasm of uterine ligament (C57.3)
  • mesothelioma (C45.-)

Official Coding Guidelines

Tx of primary site (TOC entry)

a. Admission/Encounter for treatment of primary site ............................................................. 33

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section I.C.2.a
Tx of secondary site (TOC entry)

b. Admission/Encounter for treatment of secondary site .......................................................... 33

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section I.C.2.b

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

Cite This Page

Reference C49 with the canonical source and edition:

C49 — Malignant neoplasm of other connective and soft tissue. ICD-10 Coding Pro (ICD-10-CM FY2026). https://icd10codingpro.com/codes/C49

Canonical URL: https://icd10codingpro.com/codes/C49

Related Codes

All Codes in C49

Every most-specific code under C49 Malignant neoplasm of other connective and soft tissue (20 codes):

Show the complete C49 code list
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Reviewed by Prajwal Shrestha, CPC, CRC
Certified Professional Coder (CPC) and Certified Risk Adjustment Coder (CRC) · AAPC Member ID 01997614 · About · Editorial policy · Content last reviewed: 2025-10-01

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