A51.46 Secondary syphilitic osteopathy

The ICD-10-CM code for Secondary syphilitic osteopathy is A51.46 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Chapter

1: Certain infectious and parasitic diseases (A00-B99)

Section

A50-A64: Infections with a predominantly sexual mode of transmission (A50-A64)

Category A51

18 codes (15 billable)

FY2026 Status

Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to A51.46:

• Periostitis (albuminosa) (circumscribed) (diffuse) (infective) (monomelic) › syphilitic › secondary
• Syphilis, syphilitic (acquired) › periosteum (late) › early (secondary)
• Syphilis, syphilitic (acquired) › secondary (and primary) › periosteum, periostitis
• Syphilis, syphilitic (acquired) › bone › secondary
• Syphilis, syphilitic (acquired) › secondary (and primary) › bone

U.S. Hospital Utilization

A51.46 appeared in too few sampled U.S. inpatient stays in 2020 to report a national estimate (AHRQ suppresses counts of 10 or fewer) — a rare inpatient diagnosis.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

HIV Infections (TOC entry)

a. Human Immunodeficiency Virus (HIV) Infections .............................................................. 19

Infectious agents causing diseases in other chapters (TOC)

b. Infectious agents as the cause of diseases classified to other chapters ................................. 22

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

• CMS — ICD-10-CM Official Code Set and Guidelines, FY2026
• CDC/NCHS — ICD-10-CM Files and Browser Tool
• AHRQ — HCUP National Inpatient Sample, Frequencies by Diagnosis Code (2016–2023)