ICD-10 Code for multiple sclerosis

The ICD-10-CM code for multiple sclerosis is G35 when documented without further specification. HCC RxHCC Multiple sclerosis is category G35, now split by course: relapsing-remitting (G35.A), primary progressive (G35.B-), secondary progressive (G35.C-), and unspecified (G35.D). The progressive courses further specify active vs non-active disease.

G35 is a risk-adjusting diagnosis under CMS-HCC and RxHCC models. Create a free account to see model versions, RAF contribution, and AI-powered HCC suppression analysis.

Which Code Should You Use?

What to Document

• Disease course — relapsing-remitting, primary progressive, or secondary progressive.
• For progressive courses, active vs non-active disease (the further character).
• MS diagnosis confirmation vs an isolated demyelinating episode.
• Current relapse/exacerbation status when documented.

Common Documentation Pitfalls

• G35 is a category header — assign the course-specific leaf code (G35.A/B/C/D), not bare G35.
• For primary or secondary progressive MS, specify active vs non-active rather than defaulting to the "unspecified" progressive code.

References

• CMS — ICD-10-CM Official Code Set and Guidelines, FY2026
• G35 full code details