T45.1X5 Adverse effect of antineoplastic and immunosuppressive drugs

✓ Billable ICD-10-CM 2026
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The ICD-10-CM code for Adverse effect of antineoplastic and immunosuppressive drugs is T45.1X5 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Section
T36-T50: Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances (T36-T50)
Category T45
116 codes (90 billable)
FY2026 Status
Stable since FY2024

Official Coding Guidelines

Anemia due to chemo/immuno/radiotherapy—sequence anemia first

2) Anemia associated with chemotherapy, immunotherapy and radiation therapy When the admission/encounter is for management of an anemia associated with an adverse effect of the administration of chemotherapy or immunotherapy and the only treatment is for the anemia, the anemia code is sequenced first followed by the appropriate codes for the neoplasm and the adverse effect (T45.1X5-, Adverse effect of antineoplastic and immunosuppressive drugs). When the admission/encounter is for management of an anemia associated with an adverse effect of radiotherapy, the anemia code should be sequenced first, followed by the appropriate neoplasm code and code Y84.2, Radiological procedure and radiotherapy as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure.

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section I.C.2.c.2
Sequence blood vessel/nerve injury first (fragment)

injury is to the blood vessels or nerves, that injury should be sequenced first.

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section I.C.19.b.2

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

Related Codes

Parent Code

T45 Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified

Related Codes in T45

T45 Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified T45.0 Poisoning by, adverse effect of and underdosing of antiallergic and antiemetic drugs T45.0X Poisoning by, adverse effect of and underdosing of antiallergic and antiemetic drugs T45.0X1 Poisoning by antiallergic and antiemetic drugs, accidental (unintentional) T45.0X2 Poisoning by antiallergic and antiemetic drugs, intentional self-harm T45.0X3 Poisoning by antiallergic and antiemetic drugs, assault T45.0X4 Poisoning by antiallergic and antiemetic drugs, undetermined T45.0X5 Adverse effect of antiallergic and antiemetic drugs T45.0X6 Underdosing of antiallergic and antiemetic drugs T45.1 Poisoning by, adverse effect of and underdosing of antineoplastic and immunosuppressive drugs T45.1X Poisoning by, adverse effect of and underdosing of antineoplastic and immunosuppressive drugs T45.1X1 Poisoning by antineoplastic and immunosuppressive drugs, accidental (unintentional) T45.1X2 Poisoning by antineoplastic and immunosuppressive drugs, intentional self-harm T45.1X3 Poisoning by antineoplastic and immunosuppressive drugs, assault T45.1X4 Poisoning by antineoplastic and immunosuppressive drugs, undetermined T45.1X6 Underdosing of antineoplastic and immunosuppressive drugs T45.2 Poisoning by, adverse effect of and underdosing of vitamins T45.2X Poisoning by, adverse effect of and underdosing of vitamins T45.2X1 Poisoning by vitamins, accidental (unintentional) T45.2X2 Poisoning by vitamins, intentional self-harm
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Reviewed by Prajwal Shrestha, CPC, CRC
Certified Professional Coder (CPC) and Certified Risk Adjustment Coder (CRC) · AAPC Member ID 01997614 · About · Editorial policy · Content last reviewed: 2025-10-01

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