R65.10 Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction

The ICD-10-CM code for Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction is R65.10 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Chapter

18: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99)

Section

R50-R69: General symptoms and signs (R50-R69)

Category R65

7 codes (4 billable)

FY2026 Status

Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to R65.10:

• System, systemic › inflammatory response syndrome (SIRS) of non-infectious origin (without organ dysfunction)
• Syndrome › systemic inflammatory response (SIRS), of non-infectious origin (without organ dysfunction)

Inclusion Terms

• Systemic inflammatory response syndrome (SIRS) NOS

U.S. Hospital Utilization

• An estimated 232,275 U.S. inpatient stays in 2023 included R65.10 among the documented diagnoses.
• 205 stays listed it as the principal diagnosis.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

SIRS due to noninfectious condition: code underlying, then R65.10/R65.11

g. SIRS due to Non-Infectious Process The systemic inflammatory response syndrome (SIRS) can develop as a result of certain non-infectious disease processes, such as trauma, malignant neoplasm, or pancreatitis. When SIRS is documented with a noninfectious condition, and no subsequent infection is documented, the code for the underlying condition, such as an injury, should be assigned, followed by code R65.10, Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction, or code R65.11, Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction. If an associated acute organ dysfunction is documented, the appropriate code(s) for the specific type of organ dysfunction(s) should be assigned in addition to code R65.11. If acute organ dysfunction is documented, but it cannot be determined if the acute organ dysfunction is associated with SIRS or due to another condition (e.g., directly due to the trauma), the provider should be queried.

Repeated falls vs history of falling

d. Repeated falls Code R29.6, Repeated falls, is for use for encounters when a patient has recently fallen and the reason for the fall is being investigated. Code Z91.81, History of falling, is for use when a patient has fallen in the past and is at risk for future falls. When appropriate, both codes R29.6 and Z91.81 may be assigned together.

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

• CMS — ICD-10-CM Official Code Set and Guidelines, FY2026
• CDC/NCHS — ICD-10-CM Files and Browser Tool
• AHRQ — HCUP National Inpatient Sample, Frequencies by Diagnosis Code (2016–2023)