P22.0 Respiratory distress syndrome of newborn

The ICD-10-CM code for Respiratory distress syndrome of newborn is P22.0 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Chapter

16: Certain conditions originating in the perinatal period (P00-P96)

Section

P19-P29: Respiratory and cardiovascular disorders specific to the perinatal period (P19-P29)

Category P22

5 codes (4 billable)

FY2026 Status

Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to P22.0:

• RDS (newborn) (type I)
• Hyaline membrane (disease) (lung) (pulmonary) (newborn)
• IRDS (type I)
• Respiratory › distress syndrome (newborn) (type I)
• Syndrome › IRDS (idiopathic respiratory distress, newborn)
• Syndrome › RDS (respiratory distress syndrome, newborn)
• Syndrome › cardiorespiratory distress (idiopathic), newborn
• Disease, diseased › hyaline (diffuse) (generalized) › membrane (lung) (newborn)

Inclusion Terms

• Cardiorespiratory distress syndrome of newborn
• Hyaline membrane disease
• Idiopathic respiratory distress syndrome [IRDS or RDS] of newborn
• Pulmonary hypoperfusion syndrome
• Respiratory distress syndrome, type I

U.S. Hospital Utilization

• An estimated 133,145 U.S. inpatient stays in 2023 included P22.0 among the documented diagnoses.
• 9,315 stays listed it as the principal diagnosis.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

Use of Z05 codes (newborn suspected condition ruled out)

1) Use of Z05 codes Assign a code from category Z05, Observation and evaluation of newborn for suspected diseases and conditions ruled out, to identify those instances when a healthy newborn is evaluated for a suspected condition/disease that is determined after study not to be present. Do not use a code from category Z05 when the patient is documented to have signs or symptoms of a suspected problem; in such cases code the sign or symptom.

Z05 on other than the birth record

2) Z05 on other than the birth record A code from category Z05 may also be assigned as a principal or first- listed code for readmissions or encounters when the code from category Z38 code no longer applies. Codes from category Z05 are for use only for healthy newborns and infants for which no condition after study is found to be present.

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

• CMS — ICD-10-CM Official Code Set and Guidelines, FY2026
• CDC/NCHS — ICD-10-CM Files and Browser Tool
• AHRQ — HCUP National Inpatient Sample, Frequencies by Diagnosis Code (2016–2023)