I51.81 Takotsubo syndrome
The ICD-10-CM code for Takotsubo syndrome is I51.81 (FY2026). It is a billable, claim-ready diagnosis code.
Classification
- Section
- I30-I5A: Other forms of heart disease (I30-I5A)
- Category I51
- 12 codes (10 billable)
- FY2026 Status
- Stable since FY2024
Also Known As
ICD-10-CM Alphabetic Index entries that lead to I51.81:
- Syndrome › takotsubo
- Cardiomyopathy (familial) (idiopathic) › stress induced
- Cardiomyopathy (familial) (idiopathic) › takotsubo
- Syndrome › apical ballooning (transient left ventricular)
- Syndrome › transient left ventricular apical ballooning
- Dysfunction › left ventricular, following sudden emotional stress
- Dysfunction › ventricular › left, reversible, following sudden emotional stress
Inclusion Terms
- Reversible left ventricular dysfunction following sudden emotional stress
- Stress induced cardiomyopathy
- Takotsubo cardiomyopathy
- Transient left ventricular apical ballooning syndrome
U.S. Hospital Utilization
- An estimated 52,460 U.S. inpatient stays in 2023 included I51.81 among the documented diagnoses.
- 10,690 stays listed it as the principal diagnosis.
Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.
Official Coding Guidelines
Presumed relationship due to Index term “with”The classification presumes a causal relationship between hypertension and heart involvement and between hypertension and kidney involvement, as the two conditions are linked by the term “with” in the Alphabetic Index. These conditions should be coded as related even in the absence of provider documentation explicitly linking them, unless the documentation clearly states the conditions are unrelated.
Provider must link conditions not specifically indexed as relatedFor hypertension and conditions not specifically linked by relational terms such as “with,” “associated with” or “due to” in the classification, provider documentation must link the conditions in order to code them as related.
Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026