F19.27 Other psychoactive substance dependence with psychoactive substance-induced persisting dementia

The ICD-10-CM code for Other psychoactive substance dependence with psychoactive substance-induced persisting dementia is F19.27 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Chapter

5: Mental, Behavioral and Neurodevelopmental disorders (F01-F99)

Section

F10-F19: Mental and behavioral disorders due to psychoactive substance use (F10-F19)

Category F19

79 codes (63 billable)

FY2026 Status

Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to F19.27:

• Dementia (degenerative (primary)) (persisting) (unspecified severity) (without behavioral disturbance, psychotic disturbance, mood disturbance, and anxiety) › in (due to) › psychoactive drug › with dependence
• Disorder (of) › substance use (other) (unknown) › moderate or severe › with substance-induced › major neurocognitive disorder
• Dependence (on) (syndrome) › drug NEC › psychoactive NEC › with › dementia
• Disorder (of) › cognitive › persisting › due to › specified substance NEC › with › dependence

Inclusion Terms

• Other (or unknown) substance use disorder, moderate, with other (or unknown) substance induced major neurocognitive disorder
• Other (or unknown) substance use disorder, severe, with other (or unknown) substance induced major neurocognitive disorder

U.S. Hospital Utilization

F19.27 appeared in too few sampled U.S. inpatient stays in 2023 to report a national estimate (AHRQ suppresses counts of 10 or fewer) — a rare inpatient diagnosis.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

Pain disorders related to psychological factors (TOC entry)

a. Pain disorders related to psychological factors ..................................................................... 43

Psychoactive substance use disorders (TOC entry)

b. Mental and behavioral disorders due to psychoactive substance use ................................... 43

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

• CMS — ICD-10-CM Official Code Set and Guidelines, FY2026
• CDC/NCHS — ICD-10-CM Files and Browser Tool
• AHRQ — HCUP National Inpatient Sample, Frequencies by Diagnosis Code (2016–2023)