E53.1 Pyridoxine deficiency

The ICD-10-CM code for Pyridoxine deficiency is E53.1 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Chapter

4: Endocrine, nutritional and metabolic diseases (E00-E89)

Section

E50-E64: Other nutritional deficiencies (E50-E64)

Category E53

5 codes (4 billable)

FY2026 Status

Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to E53.1:

• Deficiency, deficient › pyridoxal
• Dependence (on) (syndrome) › vitamin B6
• Syndrome › vitamin B6 deficiency
• Deficiency, deficient › pyracin (alpha) (beta)
• Avitaminosis (multiple) › B6
• Deficiency, deficient › pyridoxine (derivatives)
• Deficiency, deficient › pyridoxamine
• Deficiency, deficient › vitamin (multiple) NOS › B6

Inclusion Terms

• Vitamin B6 deficiency

U.S. Hospital Utilization

• An estimated 2,170 U.S. inpatient stays in 2023 included E53.1 among the documented diagnoses.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

Diabetes mellitus (TOC entry)

a. Diabetes mellitus ................................................................................................................... 39

Obesity (TOC entry)

b. Obesity .................................................................................................................................. 42

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

• CMS — ICD-10-CM Official Code Set and Guidelines, FY2026
• CDC/NCHS — ICD-10-CM Files and Browser Tool
• AHRQ — HCUP National Inpatient Sample, Frequencies by Diagnosis Code (2016–2023)