E28.0 Estrogen excess

The ICD-10-CM code for Estrogen excess is E28.0 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Chapter

4: Endocrine, nutritional and metabolic diseases (E00-E89)

Section

E20-E35: Disorders of other endocrine glands (E20-E35)

Category E28

11 codes (8 billable)

FY2026 Status

Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to E28.0:

• Hyperestrogenism (drug-induced) (iatrogenic)
• Hypersecretion › estrogen
• Increase, increased › estrogen
• Excess, excessive, excessively › estrogen
• Puberty (development state) › precocious (constitutional) (cryptogenic) (idiopathic) › due to › ovarian hyperfunction › estrogen

U.S. Hospital Utilization

• An estimated 80 U.S. inpatient stays in 2023 included E28.0 among the documented diagnoses.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

Diabetes mellitus (TOC entry)

a. Diabetes mellitus ................................................................................................................... 39

Obesity (TOC entry)

b. Obesity .................................................................................................................................. 42

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

• CMS — ICD-10-CM Official Code Set and Guidelines, FY2026
• CDC/NCHS — ICD-10-CM Files and Browser Tool
• AHRQ — HCUP National Inpatient Sample, Frequencies by Diagnosis Code (2016–2023)