E22.2 Syndrome of inappropriate secretion of antidiuretic hormone

The ICD-10-CM code for Syndrome of inappropriate secretion of antidiuretic hormone is E22.2 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Chapter

4: Endocrine, nutritional and metabolic diseases (E00-E89)

Section

E20-E35: Disorders of other endocrine glands (E20-E35)

Category E22

6 codes (5 billable)

FY2026 Status

Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to E22.2:

• Schwartz-Bartter syndrome
• Antidiuretic hormone syndrome
• Secretion › antidiuretic hormone, inappropriate
• Syndrome › inappropriate secretion of antidiuretic hormone
• Syndrome › Schwartz-Bartter
• Inappropriate › secretion › antidiuretic hormone (ADH) (excessive)
• Inappropriate › secretion › pituitary (posterior)
• Hypersecretion › hormone (s) › antidiuretic

U.S. Hospital Utilization

• An estimated 222,505 U.S. inpatient stays in 2023 included E22.2 among the documented diagnoses.
• 53,700 stays listed it as the principal diagnosis.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

Diabetes mellitus (TOC entry)

a. Diabetes mellitus ................................................................................................................... 39

Obesity (TOC entry)

b. Obesity .................................................................................................................................. 42

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

• CMS — ICD-10-CM Official Code Set and Guidelines, FY2026
• CDC/NCHS — ICD-10-CM Files and Browser Tool
• AHRQ — HCUP National Inpatient Sample, Frequencies by Diagnosis Code (2016–2023)