E04.1 Nontoxic single thyroid nodule

The ICD-10-CM code for Nontoxic single thyroid nodule is E04.1 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Chapter

4: Endocrine, nutritional and metabolic diseases (E00-E89)

Section

E00-E07: Disorders of thyroid gland (E00-E07)

Category E04

6 codes (5 billable)

FY2026 Status

Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to E04.1:

• Colloid nodule (of thyroid) (cystic)
• Nodule (s), nodular › colloid (cystic), thyroid
• Cyst (colloid) (mucous) (simple) (retention) › thyroid (gland)
• Thyroid (gland) (body) › nodule (cystic) (nontoxic) (single)
• Nodule (s), nodular › thyroid (cold) (gland) (nontoxic)
• Goiter (plunging) (substernal) › uninodular (nontoxic)
• Goiter (plunging) (substernal) › nontoxic › uninodular
• Struma › nodosa (simplex) › uninodular

Inclusion Terms

• Colloid nodule (cystic) (thyroid)
• Nontoxic uninodular goiter
• Thyroid (cystic) nodule NOS

U.S. Hospital Utilization

• An estimated 109,005 U.S. inpatient stays in 2023 included E04.1 among the documented diagnoses.
• 1,040 stays listed it as the principal diagnosis.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

Diabetes mellitus (TOC entry)

a. Diabetes mellitus ................................................................................................................... 39

Obesity (TOC entry)

b. Obesity .................................................................................................................................. 42

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

• CMS — ICD-10-CM Official Code Set and Guidelines, FY2026
• CDC/NCHS — ICD-10-CM Files and Browser Tool
• AHRQ — HCUP National Inpatient Sample, Frequencies by Diagnosis Code (2016–2023)