D75.81 Myelofibrosis

✓ Billable ICD-10-CM 2026
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The ICD-10-CM code for Myelofibrosis is D75.81 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Section
D70-D77: Other disorders of blood and blood-forming organs (D70-D77)
Category D75
17 codes (13 billable)
FY2026 Status
Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to D75.81:

  • Myelofibrosis
  • Osteosclerosis › myelofibrosis
  • Myelofibrosis › secondary
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › myelofibrosis
Excludes1
Not coded here. These conditions should NOT be coded together with D75.81.
  • acute myelofibrosis (C94.4-)
  • idiopathic myelofibrosis (D47.1)
  • leukoerythroblastic anemia (D61.82)
  • myelofibrosis with myeloid metaplasia (D47.4)
  • myelophthisic anemia (D61.82)
  • myelophthisis (D61.82)
  • primary myelofibrosis (D47.1)
Code First
  • the underlying disorder, such as:
  • malignant neoplasm of breast (C50.-)
Use Additional Code
  • code, if applicable, for associated therapy-related myelodysplastic syndrome (D46.-)
  • code for adverse effect, if applicable, to identify drug (T45.1X5)

Inclusion Terms

  • Myelofibrosis NOS
  • Secondary myelofibrosis NOS

U.S. Hospital Utilization

  • An estimated 9,980 U.S. inpatient stays in 2023 included D75.81 among the documented diagnoses.
  • 95 stays listed it as the principal diagnosis.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

Chapter 3 TOC entry

3. Chapter 3: Disease of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) ............................................................................................. 39

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section I.C.3
Reserved for future guideline expansion

Reserved for future guideline expansion ...................................................................................... 39

— ICD-10-CM Official Guidelines for Coding and Reporting, FY2026, Section I.C.3.Reserved

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

Related Codes

Parent Code

D75 Other and unspecified diseases of blood and blood-forming organs

Related Codes in D75

D75 Other and unspecified diseases of blood and blood-forming organs D75.0 Familial erythrocytosis D75.1 Secondary polycythemia D75.8 Other specified diseases of blood and blood-forming organs D75.82 Heparin induced thrombocytopenia (HIT) D75.821 Non-immune heparin-induced thrombocytopenia D75.822 Immune-mediated heparin-induced thrombocytopenia D75.828 Other heparin-induced thrombocytopenia syndrome D75.829 Heparin-induced thrombocytopenia, unspecified D75.83 Thrombocytosis D75.838 Other thrombocytosis D75.839 Thrombocytosis, unspecified D75.84 Other platelet-activating anti-PF4 disorders D75.89 Other specified diseases of blood and blood-forming organs D75.9 Disease of blood and blood-forming organs, unspecified D75.A Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia
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Reviewed by Prajwal Shrestha, CPC, CRC
Certified Professional Coder (CPC) and Certified Risk Adjustment Coder (CRC) · AAPC Member ID 01997614 · About · Editorial policy · Content last reviewed: 2025-10-01

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