D59.31 Infection-associated hemolytic-uremic syndrome
The ICD-10-CM code for Infection-associated hemolytic-uremic syndrome is D59.31 (FY2026). It is a billable, claim-ready diagnosis code.
Classification
- Section
- D55-D59: Hemolytic anemias (D55-D59)
- Category D59
- 19 codes (16 billable)
- FY2026 Status
- Stable since FY2024
Also Known As
ICD-10-CM Alphabetic Index entries that lead to D59.31:
- Syndrome › hemolytic-uremic › Shiga toxin-producing E. coli [STEC] related
- Syndrome › hemolytic-uremic › typical
- Syndrome › hemolytic-uremic › infection-associated
- Syndrome › hemolytic-uremic › atypical › infection-associated
Inclusion Terms
- Shiga toxin-producing E. coli [STEC] related hemolytic uremic syndrome
- Typical hemolytic uremic syndrome
U.S. Hospital Utilization
- An estimated 585 U.S. inpatient stays in 2023 included D59.31 among the documented diagnoses.
- 275 stays listed it as the principal diagnosis.
Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.
Official Coding Guidelines
Exception: HIV + hemolytic-uremic syndrome sequencingAn exception to this guideline is if the reason for admission is hemolytic-uremic syndrome associated with HIV disease. Assign code D59.31, Infection-associated hemolytic-uremic syndrome, followed by code B20, Human immunodeficiency virus [HIV] disease.
Hemolytic-uremic syndrome associated with sepsis9) Hemolytic-uremic syndrome associated with sepsis If the reason for admission is hemolytic-uremic syndrome that is associated with sepsis, assign code D59.31, Infection-associated hemolytic-uremic syndrome, as the principal diagnosis. Codes for the underlying systemic infection and any other conditions (such as severe sepsis) should be assigned as secondary diagnoses.
Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026