D49.6 Neoplasm of unspecified behavior of brain

The ICD-10-CM code for Neoplasm of unspecified behavior of brain is D49.6 (FY2026). It is a billable, claim-ready diagnosis code.

Classification

Chapter

2: Neoplasms (C00-D49)

Section

D49: Neoplasms of unspecified behavior (D49)

Category D49

18 codes (14 billable)

FY2026 Status

Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to D49.6:

• Degeneration, degenerative › brain (cortical) (progressive) › in › neoplastic disease

U.S. Hospital Utilization

• An estimated 10,925 U.S. inpatient stays in 2023 included D49.6 among the documented diagnoses.
• 4,485 stays listed it as the principal diagnosis.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

Tx of primary site (TOC entry)

a. Admission/Encounter for treatment of primary site ............................................................. 33

Tx of secondary site (TOC entry)

b. Admission/Encounter for treatment of secondary site .......................................................... 33

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

• CMS — ICD-10-CM Official Code Set and Guidelines, FY2026
• CDC/NCHS — ICD-10-CM Files and Browser Tool
• AHRQ — HCUP National Inpatient Sample, Frequencies by Diagnosis Code (2016–2023)