C96.0 Multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis
The ICD-10-CM code for Multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis is C96.0 (FY2026). It is a billable, claim-ready diagnosis code.
Classification
- Chapter
- 2: Neoplasms (C00-D49)
- Section
- C81-C96: Malignant neoplasms of lymphoid, hematopoietic and related tissue (C81-C96)
- Category C96
- 13 codes (11 billable)
- FY2026 Status
- Stable since FY2024
Also Known As
ICD-10-CM Alphabetic Index entries that lead to C96.0:
- Letterer-Siwe's disease
- Reticuloendotheliosis › nonlipid
- Histiocytosis › acute differentiated progressive
- Reticuloendotheliosis › acute infantile
- Reticulosis (skin) › acute of infancy
- Histiocytosis › X NEC › acute (progressive)
- Histiocytosis › X NEC › multisystemic
- Histiocytosis › Langerhans' cell NEC › multifocal X › multisystemic (disseminated)
Inclusion Terms
- Histiocytosis X, multisystemic
- Letterer-Siwe disease
U.S. Hospital Utilization
- An estimated 95 U.S. inpatient stays in 2023 included C96.0 among the documented diagnoses.
Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.
Official Coding Guidelines
Tx of primary site (TOC entry)a. Admission/Encounter for treatment of primary site ............................................................. 33
Tx of secondary site (TOC entry)b. Admission/Encounter for treatment of secondary site .......................................................... 33
Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026