C88.2 Heavy chain disease

The ICD-10-CM code for Heavy chain disease is C88.2 (FY2026). It is a non-billable category code — select a more specific code below for claims.

Classification

Chapter

2: Neoplasms (C00-D49)

Section

C81-C96: Malignant neoplasms of lymphoid, hematopoietic and related tissue (C81-C96)

Category C88

19 codes (12 billable)

FY2026 Status

Stable since FY2024

Also Known As

ICD-10-CM Alphabetic Index entries that lead to C88.2:

• Franklin disease
• Disease, diseased › Franklin
• Disease, diseased › mu heavy chain disease
• Disease, diseased › heavy chain NEC
• Disease, diseased › gamma heavy chain
• Disease, diseased › heavy chain NEC › gamma
• Disease, diseased › heavy chain NEC › mu

Inclusion Terms

• Franklin disease
• Gamma heavy chain disease
• Mu heavy chain disease

U.S. Hospital Utilization

• An estimated 70 U.S. inpatient stays in 2023 included C88.2 among the documented diagnoses.

Source: National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, 2016–2023. National survey-weighted estimates.

Official Coding Guidelines

Tx of primary site (TOC entry)

a. Admission/Encounter for treatment of primary site ............................................................. 33

Tx of secondary site (TOC entry)

b. Admission/Encounter for treatment of secondary site .......................................................... 33

Source: CMS — ICD-10-CM Official Guidelines for Coding and Reporting, FY2026

References

• CMS — ICD-10-CM Official Code Set and Guidelines, FY2026
• CDC/NCHS — ICD-10-CM Files and Browser Tool
• AHRQ — HCUP National Inpatient Sample, Frequencies by Diagnosis Code (2016–2023)